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Intestin et microbiome

Helicobacter pylori

Pathogenic bacterium of the stomach causing gastritis and ulcers.

Definition

A pathogenic bacterium colonizing the stomach that can cause gastritis, gastric and duodenal ulcers, and increase the risk of gastric cancer.

How it works

Helicobacter pylori is a unique, Gram-negative, microaerophilic bacterium capable of surviving in the acidic environment of the stomach. It colonizes the gastric mucosa and causes chronic inflammation, potentially progressing to ulcers, atrophic gastritis, and gastric cancer. Transmission occurs through the oral-fecal or oral-oral route. It is responsible for the majority of gastric ulcers before the antibiotic era. Eradication with triple or quadruple therapy significantly reduces the risk of severe complications.

Role

Opportunistic pathogen causing gastric inflammation and ulcerative complications.

Examples

  • H. pylori strain 26695
  • H. pylori J99
  • Familial transmission
  • Global prevalence of 30-50%

Recommendations

Have your H. pylori tested with a respiratory or serologic test if you have persistent gastric symptoms. Follow the prescribed treatment (triple or quadruple antibiotic therapy) precisely and complete it with an anti-inflammatory diet rich in antioxidants during and after.

Key takeaway

Helicobacter pylori is a treatable pathogen that prevents severe complications through eradication.

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