mTOR

Definition

Central protein kinase (mammalian Target of Rapamycin) regulating cellular growth, protein synthesis, and energetic metabolism.

How it works

mTOR is a major protein controlling anabolism (growth and protein synthesis) and inhibiting autophagy. Although growth is essential in youth, chronic activation of mTOR accelerates aging and increases the risk of metabolic and cancerous diseases. The ideal balance consists of maintaining moderate mTOR activity to preserve muscle function while allowing autophagy. Caloric restriction, fasting, and certain nutrients (polyphenols) inhibit mTOR, whereas branched-chain amino acids and insulin activate it. Maximum longevity is achieved by intelligently modulating mTOR activity according to needs.

Role

Regulate the balance between cellular growth and repair for optimal longevity and metabolic health.

Examples

• Complete proteins (eggs, fish) activate mTOR
• Caloric restriction inhibits mTOR
• Red wine polyphenols inhibit mTOR
• Prolonged fasting suppresses mTOR
• Rapamycin (medication) specifically inhibits mTOR

Recommendations

Alternate between periods of mTOR activation (protein-rich nutrition) and inhibition (fasting, caloric restriction) for optimal balance. Enrich your diet with polyphenols and antioxidants that favorably modulate mTOR. Adapt your approach to your age and health goals.

Key takeaway

Balancing mTOR activity between growth and repair cellular mechanisms through intelligent nutritional cycles is essential for healthy longevity.

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