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Intestin et microbiome

Clostridium

Mixed bacterium genus with both beneficial and pathogenic effects

Definition

Gram-positive anaerobic bacterium genus including both beneficial and pathogenic species, such as Clostridium difficile.

How it works

The Clostridium genus is complex: some clusters produce beneficial butyrate, while others, notably Clostridium difficile, are opportunistic pathogens. Clostridium difficile proliferates in dysbiosis and antibiotic treatments, producing toxins causing severe intestinal infections.

Role

Can be beneficial (production of butyrate) or pathogenic (inflammation and infections)

Examples

  • Clostridium difficile (pathogen)
  • Clostridium cluster IV (beneficial)
  • Clostridium cluster XIVa (beneficial)
  • Faecalibacterium prausnitzii (Clostridium group IV)

Recommendations

Avoid unnecessary antibiotics that favor Clostridium difficile. Maintain a rich and diverse flora with a varied diet rich in fibers to naturally inhibit pathogens.

Key takeaway

The pathogenic Clostridium prospers in dysbiosis; maintain a healthy flora to naturally control it

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