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Immunité et nutrition

Glutathione

Glutathione is the body's most important intracellular antioxidant for immune protection.

Definition

The body's master antioxidant tripeptide that protects cells from oxidative damage and is crucial for immune cell function, particularly in lymphocytes.

How it works

Glutathione (GSH) is a tripeptide composed of three amino acids—glutamic acid, cysteine, and glycine—that serves as the body's primary intracellular antioxidant. It neutralizes reactive oxygen species, detoxifies harmful compounds, and recycles other antioxidants like vitamins C and E, making it essential for cellular defense. Immune cells, particularly T cells and lymphocytes, require adequate glutathione levels to proliferate and function optimally; glutathione deficiency is associated with impaired immune responses. The body synthesizes glutathione from amino acids, but synthesis can be compromised by inadequate protein intake, age, chronic disease, or oxidative stress. While dietary sources like cruciferous vegetables, asparagus, and garlic provide precursors, supporting glutathione synthesis requires adequate protein, sulfur-containing amino acids (cysteine and methionine), and cofactors like selenium and vitamin B6.

Role

Serves as the primary intracellular antioxidant protecting immune cells and supporting their proliferation and function.

Examples

  • Cruciferous vegetables like broccoli and Brussels sprouts
  • Asparagus
  • Garlic
  • Onions
  • Eggs
  • Grass-fed beef

Recommendations

Support glutathione synthesis through adequate protein intake (0.8-1g per kg of body weight) emphasizing sulfur-containing amino acids. Consume cruciferous vegetables daily, either raw or lightly steamed to preserve sulfur compounds. Include selenium and B6-rich foods to support glutathione regeneration.

Key takeaway

Optimal glutathione status, supported through protein-rich nutrition and cruciferous vegetables, is essential for immune cell protection and function.

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