Adiponectin

Definition

Adipokine secreted by adipose tissue that improves insulin sensitivity and promotes fatty acid oxidation.

How it works

Adiponectin is a protein hormone produced by fatty cells with a beneficial role for metabolic health. It increases insulin sensitivity, promotes the burning of fats in muscles and liver, and reduces systemic inflammation. Unlike other adipokines, adiponectin decreases with increased body fat, creating a protective paradox: the thinner you are, the more you produce it. Low levels of adiponectin are associated with metabolic syndrome and type 2 diabetes.

Role

Improves insulin sensitivity and promotes fatty acid oxidation.

Examples

• High in slender individuals
• Reduced in overweight or obesity
• Increase after weight loss
• Improvement with regular physical exercise

Recommendations

Practice regular physical activity to increase adiponectin. Maintain a healthy weight as adiponectin is inversely proportional to body fat. Consume anti-inflammatory foods rich in polyphenols.

Key takeaway

Adiponectin is protective for metabolism but decreases with obesity.

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