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Macronutrients – Carbohydrates

Fructose

Simple sugar found in fruits and sweeteners that is metabolized differently than glucose.

Definition

A monosaccharide simple sugar naturally found in fruits, honey, and processed foods that is metabolized primarily in the liver.

How it works

Fructose is a 6-carbon monosaccharide with the same molecular formula as glucose (C6H12O6) but a different structure. Unlike glucose, which is regulated by insulin, fructose is metabolized primarily in the liver through a pathway that is not regulated by insulin, making it metabolically distinct. While fructose has a lower glycemic index than glucose, excessive consumption—particularly from high-fructose corn syrup in processed foods—has been linked to fatty liver disease, metabolic syndrome, and elevated triglycerides. Natural dietary fructose from whole fruits includes beneficial fiber and micronutrients.

Role

Provides energy through liver metabolism but excessive intake can promote lipogenesis (fat storage) and metabolic dysfunction.

Examples

  • Apples
  • Pears
  • Honey
  • Agave nectar
  • High-fructose corn syrup
  • Dried fruits
  • Fruit juices

Recommendations

Obtain fructose primarily from whole fruits and natural sources. Limit processed foods and sugary beverages containing high-fructose corn syrup. Consume fruit with skin and fiber intact to moderate fructose absorption.

Key takeaway

While fructose from whole fruits is nutritious, excessive fructose from sweeteners and processed foods promotes metabolic dysfunction.

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