Genetically determined lipoprotein particle associated with increased cardiovascular risk.
A lipoprotein particle composed of LDL and apolipoprotein(a). Independent genetic risk factor for atherosclerosis and thrombosis.
Lp(a) is a variant of LDL where apolipoprotein B100 is linked to apo(a) by a disulfide bond. Unlike other lipoproteins, Lp(a) levels are primarily determined genetically and little influenced by dietary regimen or usual medications. Lp(a) favors both atherosclerosis and thrombosis (clot formation), increasing the risk of heart attack and stroke. Elevated Lp(a) levels are a major independent risk factor even with normal cholesterol levels.
Increases the risk of atherosclerosis and thrombosis through pro-inflammatory and pro-coagulant mechanisms.
Have Lp(a) tested at least once in life, particularly with a family history of cardiovascular disease. For high levels, consider specific treatments (asopcimab, inclisiran) in consultation with a cardiologist.
Lp(a) is a powerful genetic risk factor justifying aggressive management of the overall lipid profile.
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