Apo-B

Definition

Apo-protein B is the main structural protein of atherogenic lipoproteins (VLDL, LDL, Lp(a)). Key marker of the number of atherogenic particles circulating in the blood.

How it works

Apo-protein B is a protein present in a single copy on each atherogenic lipoprotein (VLDL, LDL, Lp(a)). It thus serves as a marker of the actual number of atherogenic particles circulating in the blood, independently of their cholesterol content. A high Apo-B level indicates more particles capable of penetrating the arterial wall and forming atherosclerotic plaques. It is a predictor of cardiovascular risk often more reliable than LDL-C alone.

Role

Identifies and quantifies the number of lipid particles potentially atherogenic.

Examples

• Elevated Apo-B levels with normal LDL-C
• Small number of large LDL particles
• Dense and small particles rich in triglycerides

Recommendations

Ask for Apo-B testing for better risk assessment if cardiovascular risk factors are present. Maintain an Apo-B level below 80 mg/dL for optimal protection.

Key takeaway

Apo-B measures the number of atherogenic particles, which is a better predictor of cardiovascular risk than LDL-C alone.

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