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Micronutrients – Water-Soluble Vitamins

Pyridoxine

Pyridoxine is vitamin B6, essential for protein and neurotransmitter metabolism.

Definition

Pyridoxine is the chemical name for vitamin B6, a water-soluble vitamin that is converted into its active coenzyme form, pyridoxal-5-phosphate (PLP), essential for amino acid and neurotransmitter metabolism.

How it works

Pyridoxine, once absorbed, is rapidly converted to pyridoxal-5-phosphate (PLP), the metabolically active coenzyme form that functions in the metabolism of all amino acids. PLP is particularly important in transamination reactions, where amino groups are transferred between amino acids and carbon skeletons, allowing the body to synthesize non-essential amino acids. The vitamin is also critical for one-carbon metabolism, working in conjunction with folate and B12 to regulate homocysteine levels. Pyridoxine supports the synthesis of neurotransmitters critical for mood and cognitive function, making it important for mental health. Additionally, it plays roles in gene expression, immune regulation, and the synthesis of hemoglobin. The body stores limited amounts of pyridoxine, making consistent dietary intake necessary.

Role

Coenzyme for amino acid metabolism, neurotransmitter synthesis, and one-carbon metabolism.

Examples

  • Chickpeas and other legumes
  • Salmon and other fish
  • Chicken breast
  • Potatoes
  • Bananas
  • Sunflower and pumpkin seeds

Recommendations

Meet daily requirements of 1.3-1.7 mg through varied food sources, with higher needs during pregnancy and lactation. Include plant-based B6 sources for vegetarians and vegans.

Key takeaway

Pyridoxine is essential for protein metabolism, brain chemistry, and overall metabolic health.

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