Ovarian Reserve

Definition

Number and quality of available oocytes in the ovaries. It declines progressively with age and directly impacts fertility and response to fertility treatments.

How it works

Ovarian Reserve is genetically determined but quality can be optimized through nutrition. Oocytes are particularly sensitive to oxidative stress, damaging mitochondrial DNA and nuclear quality. Antioxidants (vitamins C, E, selenium, CoQ10, DHEA) protect ovary mitochondrial cells and slow their aging. Adequate nutrition improves the follicular microenvironment and favors optimal nuclear reaction. While the number of oocytes cannot be increased, their quality can be significantly improved.

Role

Determines reproductive capacity and response to hormonal stimulation in fertility treatments.

Examples

• Antimüllerian hormone marker
• Follicle count
• Previous ovarian response
• Decreased reserve linked to age
• Quality possible improvement using antioxidants

Recommendations

For women with low reserve, begin antioxidant supplementation 3-6 months before fertility treatments: CoQ10 (600mg/day in divided doses), DHEA (25mg x3/day), selenium, and vitamins C, E. Maintain a healthy weight and reduce stress.

Key takeaway

While not augmentable, ovarian reserve quality can be optimized through targeted antioxidant nutrition.

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